On 3 Sep 1827 when Darius was 26, he married Arelia Doolittle (63691) , daughter of Daniel Doolittle (61699) (27 Oct 1768-21 Feb 1850) & Dinah Chatterton (57642) (17 Mar 1768-13 Jun 1847), in Hamden, CT. Born on 22 Apr 1809 in Hamden, CT. Arelia died on 8 Apr 1864; she was 54.

Children of Darius and Amelia (Doolittle) Sanford, born at Hamden:
    i. Amelia Ann Sanford, b. 24 Dec 1828;
    ii. Martha Mary Sanford, b. 28 Nov 1829;
    iii. Emeline Francis Sanford, b. 12 Sep 1832;
    iv. Phidelia Sanford, b. 24 Sep 1834; and
    v. Elizabeth Sanford, b. 28 Sep 1836.